Antibody arrays
نویسندگان
چکیده
منابع مشابه
Antibody arrays in cancer research.
Antibody arrays have valuable applications in cancer research. Many different antibody array technologies have been developed, each with particular advantages, disadvantages, and optimal applications. The methods have been demonstrated on various sample types, such as serum, plasma, and other bodily fluids; cell culture supernatants; tissue culture lysates; and resected tumor specimens. The app...
متن کاملAntigen arrays for antibody profiling.
Antigen array technologies enable large-scale profiling of the specificity of antibody responses against autoantigens, tumor antigens and microbial antigens. Antibody profiling will provide insights into pathogenesis, and will enable development of novel tests for diagnosis and guiding therapy in the clinic. Recent advances in the field include development of antigen array-based approaches to e...
متن کاملHuman Antibody Profiling with TruePlexTM Antibody Profiling Arrays Introduction
Many disease biomarkers are expressed at relatively low levels or are not secreted making them difficult to detect in serum or plasma. However, these biomarkers can stimulate a robust humoral immune response even if the antigens are expressed at very low levels. Because the immune system serves as a natural amplification system, antibodies to these biomarkers can be produced at detectable level...
متن کاملSandwich Antibody Arrays Using Recombinant Antibody-Binding Protein L
Antibody arrays are a useful for detecting antigens and other antibodies. This technique typically requires a uniform and well-defined orientation of antibodies attached to a surface for optimal performance. A uniform orientation can be achieved by modification of antibodies to include a single site for attachment. Thus, uniformly oriented antibody arrays require a bioengineered modification fo...
متن کاملPhosphokinase Antibody Arrays on Dendron-Coated Surface
Monitoring protein phosphorylation at the cellular level is important to understand the intracellular signaling. Among the phosphoproteomics methods, phosphokinase antibody arrays have emerged as preferred tools to measure well-characterized phosphorylation in the intracellular signaling. Here, we present a dendron-coated phosphokinase antibody array (DPA) in which the antibodies are immobilize...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2000
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20000906-03